The Well-Worn Route and the Path Less Traveled

The Well-Worn Route and the Path Less Traveled Distinct Neural Bases of Route Following and Wayfinding in Humans

Finding one's way in a large-scale environment may engage different cognitive processes than following a familiar route. The neural bases of these processes were investigated using functional MRI (fMRI). Subjects found their way in one virtual-reality town and followed a well-learned route in another. In a control condition, subjects followed a visible trail. Within subjects, accurate wayfindin...

The path(way) less traveled.

In this issue of Blood, Mathewson et al characterized targeting a novel intracellular pathway with an agent known to induce potent antitumor effects but now also appears to potently suppress inflammatory responses by dendritic cells (DCs) and prevent graft-vs-host disease (GVHD). Identifying agents that can suppress GVHD yet not compromise graft-vs-tumor (GVT) effects remains a paramount goal i...

Meiotic Recombination: Taking the Path Less Traveled

The proper distribution of crossovers during meiosis I ensures accurate chromosome segregation at the first meiotic division. A new study reveals both the consequences of improper crossover patterning in Drosophila and the role of Blm helicase in controlling this patterning.

The road less traveled.

The road less traveled

Phagosomes containing the bacterial pathogen Legionella pneumophila are transported to the ER after macrophage internalization. To modulate phagosome transport, Legionella use a specialized secretion system that injects bacterial proteins into eukaryotic cells. This review will focus on recent studies that have identified bacterial proteins and host processes that play a concerted role in trans...